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Human cases are sporadic and most commonly associated with people working in proximity to infected animals [33]

Critical care toxicology: diagnosis and management of the critically poisoned patient 27912794

Mol Aspects Med (2004) 25:1726

PMID: 19464452

Ding Nan and Weiping Yao contribute equally to this work

The genetic alteration is directly related to impairment of myeloid maturation at the promyelocyte stage, often resulting in the accumulation of blasts with the appearance of abnormal promyelocytes in the bone marrow and/or peripheral blood, along with consequent cytopenias as well as a typical coagulopathy that manifests as a high risk of bleeding and requires rapid diagnosis and treatment to prevent early fatality